Diseases and Conditions

For such a small organ, a tremendous range of retinal diseases have been described. Some of the most common retinal conditions are listed below.

Age-related macular degeneration (AMD) is a deterioration of the retina and choroid that leads to a substantial loss in visual acuity (sharpness of vision). AMD is the leading cause of significant visual acuity loss in people over age 50 in developed countries.

Central retinal vein occlusion, also known as CRVO, is a condition in which the main vein that drains blood from the retina closes off partially or completely. This can cause blurred vision and other problems with the eye.

Retinal artery occlusion refers to blockage of the retinal artery carrying oxygen to the nerve cells in the retina at the back of the eye. The lack of oxygen delivery to the retina may result in severe loss of vision.

Central serous chorioretinopathy, commonly referred to as CSC, is a condition in which fluid accumulates under the retina, causing a serous (fluid-filled) detachment and vision loss.

CSC most often occurs in young and middle-aged adults. For unknown reasons, men develop this condition more commonly than women. Vision loss is usually temporary but sometimes can become chronic or recur.

Diabetic retinopathy is a complication of diabetes that causes damage to the blood vessels of the retina— the light-sensitive tissue that lines the back part of the eye, allowing you to see fine detail.

Diabetic retinopathy is the most common cause of irreversible blindness in working-age Americans. As many people with type 1 diabetes suffer blindness as those with the more common type 2 disease. Diabetic retinopathy occurs in more than half of the people who develop diabetes.

Cataract surgery is one of the most common and successful surgical procedures performed today. Over the past decade, the risk of severe complications has decreased with advances in surgical instruments and techniques. In the procedure, the cataract (cloudy lens) is removed, and a clear intraocular (in-the-eye) lens is placed. Rare complications include intraocular lens (IOL) dislocation, where the lens moves out of place.

Epiretinal membrane (ERM), also commonly known as cellophane maculopathy or macular puckers, are avascular (having few or no blood vessels), semitranslucent, fibrocellular membranes that form on the inner surface of the retina. They most commonly cause minimal symptoms and can be simply observed, but in some cases they can result in painless loss of vision and metamorphopsia (visual distortion). Generally, ERMs are most symptomatic when affecting the macula, which is the central portion of the retina that helps us to distinguish fine detail used for reading and recognizing faces.

Posterior Vitreous Detachment (PVD) is a natural change that occurs during adulthood, when the vitreous gel that fills the eye separates from the retina, the light-sensing nerve layer at the back of the eye.

The macula is a small area in the center of the retina where light is sharply focused to produce the detailed color vision needed for tasks such as reading and driving. When a full-thickness defect develops in the macula, the condition is referred to as macular hole.

The retina lines the back wall of the eye, and is responsible for absorbing the light that enters the eye and converting it into an electrical signal that is sent to the brain via the optic nerve, allowing you to see. Many conditions can lead to a retinal detachment, in which the retina separates from the back wall of the eye, like wallpaper peeling off a wall.

The retina is the inner lining of the eye; it is the thin, light-sensitive tissue that generates vision. Tears can form in the retina, creating a risk of retinal detachment and severe loss of vision.

The vitreous humor is a transparent, gel-like material that fills the space within the eye between the lens and the retina. The vitreous is encapsulated in a thin shell called the vitreous cortex, and the cortex in young, healthy eyes is usually sealed to the retina.

As the eye ages, or in certain pathologic conditions, the vitreous cortex can pull away from the retina, leading to a condition known as posterior vitreous detachment (PVD). This detachment usually occurs as part of the normal aging process.

There are instances where a PVD is incomplete, leaving the vitreous partially attached to the retina, and causing tractional (pulling) forces that can cause anatomical damage. The resulting condition is called vitreomacular traction (VMT) syndrome.

VMT syndrome can lead to different maculopathies or disorders in the macular area (at the center of the retina), such as full- or partial-thickness macular holes, epiretinal membranes, and cystoid macular edema. These disorders are often associated with reduced sharpness of vision (visual acuity) or other visual complications.